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"en": "Pharmacokinetics and brain penetration of carbapenems in mice"
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"en": [
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"name": "Kazuaki Matsumoto"
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{
"name": "Yuji Kurihara"
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"description": {
"en": "An adverse effect associated with the administration of carbapenems is central nervous system (CNS) toxicity, with higher brain concentrations of carbapenems being linked to an increased risk of seizures. However, the pharmacokinetics and brain penetration of carbapenems have not yet been examined. Thus, the aim of this in vivo investigation was to determine the pharmacokinetics and brain penetration of carbapenems in mice.\nBlood samples and brain tissue samples were obtained 10, 20, 30, 60, and 120 min after the subcutaneous administration of carbapenems (91 mg/kg). We obtained the following values for the pharmacokinetic parameters of carbapenems in mice: 1.20-1.71 L/h/kg for CLtotal/F, 1.41-2.03 h(-1) for K-e, 0.34-0.51 h for T-1/2, 0.66-0.95 L/kg for V-ss/F, 0.49-0.73 h for MRT, 83.46-110.58 mu g/mL for C-max, (plasma), and 0.28-0.83 mu g/g for C-max,C- (brain tissue). The AUC(0-infinity) of the carbapenems tested in plasma were in the following order: doripenem > meropenem > biapenem > imipenem, and in brain tissue were: imipenem > doripenem > meropenem > biapenem. The degrees of brain tissue penetration, defined as the AUC(0-infinity), (brain) (tissue)/fAUC(0-infinity,) (plasma) ratio, were 0.016 for imipenem, 0.004 for meropenem, 0.002 for biapenem, and 0.008 for doripenem.\nThe results of the present study demonstrated that, of the carbapenems examined, imipenem penetrated brain tissue to the greatest extent. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved."
},
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"ja": "医薬品副作用被害救済制度からみた抗菌薬が関連した副作用被害の実態.",
"en": "医薬品副作用被害救済制度からみた抗菌薬が関連した副作用被害の実態."
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"ja": [
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"name": "木津 純子"
},
{
"name": "佐藤沙紀"
},
{
"name": "松元一明"
},
{
"name": "黒田裕子"
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{
"name": "木津純子"
}
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"en": "日本化学療法学会"
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"paper_title": {
"ja": "自動車運転に影響を及ぼす医薬品の処方における薬局薬剤師の対応",
"en": "自動車運転に影響を及ぼす医薬品の処方における薬局薬剤師の対応"
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"authors": {
"ja": [
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{
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{
"name": "松元一明"
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{
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{
"name": "木津純子"
}
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}
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"ja": "日本交通科学協議会",
"en": "日本交通科学協議会"
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"ja": "日本交通科学協議会誌",
"en": "日本交通科学協議会誌"
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"en": "Anti-inflammatory effects of linezolid on carrageenan-induced paw edema in rats"
},
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"en": [
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"name": "Kazuaki Matsumoto"
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{
"name": "Shigeaki Obara"
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{
"name": "Yuko Kuroda"
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{
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"description": {
"en": "The immunomodulatory activity of linezolid has recently been reported using in vitro experimental models. However, the anti-inflammatory activity of linezolid has not yet been demonstrated using in vivo experimental models. Therefore, the aim of the present study was to demonstrate the anti-inflammatory activity of linezolid and other anti-MRSA agents using the carrageenan-induced rat paw edema model.The pretreatment with 50 mg/kg linezolid significantly suppressed edema rates, compared with control (5% glucose), with edema rates at 0.5 and 3 h after the administration of carrageenan being 17.3 ± 3.5 and 30.8 ± 3.0%, respectively. On the other hand, edema rates were not suppressed by the pretreatments with 50 mg/kg vancomycin, teicoplanin, arbekacin, and daptomycin. Furthermore, we demonstrated that linezolid exhibited anti-inflammatory activity in a concentration-dependent manner. These effects were observed at linezolid concentrations that are achievable in human serum with conventional dosing.In conclusion, the results of the present study suggest that the anti-inflammatory activities of linezolid, in addition to its antimicrobial effects, have a protective effect against destructive inflammatory responses in areas of inflammation."
},
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"en": "Elsevier"
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"en": "Journal of Infection and Chemotherapy"
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"10.1016/j.jiac.2015.08.004"
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"1341-321X"
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"en": "Basic studies on the stability of flavored oral solutions of rebamipide",
"ja": "フレーバー添加レバミピド内用液剤の安定性に関する基礎検討"
},
"authors": {
"ja": [
{
"name": "木津 純子"
},
{
"name": "矢島領"
},
{
"name": "今岡楓太"
},
{
"name": "輪湖哲也"
},
{
"name": "黒田裕子"
},
{
"name": "松元一明"
},
{
"name": "木津純子"
},
{
"name": "片山志郎"
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"en": [
{
"name": "Ryo Yajima"
},
{
"name": "Futa Imaoka"
},
{
"name": "Tetsuya Wako"
},
{
"name": "Yuko Kuroda"
},
{
"name": "Kazuaki Matsumoto"
},
{
"name": "Junko Kizu"
},
{
"name": "Shiro Katayama"
}
]
},
"description": {
"en": "Stomatitis frequently occurs during chemotherapy and radiotherapy for cancer. Because of its pharmacological properties including anti-inflammatory activity and stimulatory effects on endogenous prostaglandin synthesis, rebamipide has been suggested as a potentially effective treatment against stomatitis. In the present study we tested the stability of oral rebamipide solutions prepared in our hospital pharmacy using sodium alginate as a thickener to increase retention of this agent in the oral cavity, and the addition of different flavoring mixtures intended for use in enteral diets to reduce the bitterness of rebamipide and sodium alginate. Samples of oral rebamipide solution prepared with 13 kinds of flavoring and sodium alginate were evaluated in terms of their appearance, redispersibility, pH, viscosity, and rebamipide content immediately after preparation and 1, 3, 7, and 10 days after storage at room temperature under ambient light or in a cool, dark place. After 10 days of storage, favorable stability was observed in four sample solutions supplemented with green apple, pineapple, yogurt, and tomato flavoring mixtures intended for use in Elental® diets. These oral solutions may have potential clinical application."
},
"publisher": {
"en": "Pharmaceutical Society of Japan"
},
"publication_date": "2015-12-01",
"publication_name": {
"en": "Yakugaku Zasshi",
"ja": "YAKUGAKU ZASSHI"
},
"volume": "135",
"number": "12",
"starting_page": "1397",
"ending_page": "1402",
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],
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"doi": [
"10.1248/yakushi.15-00177"
],
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"1347-5231",
"0031-6903"
],
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"26632156"
],
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"ja": "溶出性・分割性からみた市販アセトアミノフェン坐剤の比較",
"en": "溶出性・分割性からみた市販アセトアミノフェン坐剤の比較"
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{
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{
"name": "徳田真実"
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{
"name": "井上舞鳥"
},
{
"name": "増田克哉"
},
{
"name": "寺島朝子"
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{
"name": "前澤佳代子"
},
{
"name": "松元一明"
},
{
"name": "木津純子"
}
],
"en": [
{
"name": "KIZU Junko"
}
]
},
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"ja": "医療薬学",
"en": "医療薬学"
},
"volume": "41",
"starting_page": "714",
"ending_page": "721",
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],
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"paper_title": {
"ja": "小児急性リンパ性白血病の維持療法期間におけるメルカプトプリン及びメトトレキサート投与量の推移",
"en": "小児急性リンパ性白血病の維持療法期間におけるメルカプトプリン及びメトトレキサート投与量の推移"
},
"authors": {
"en": [
{
"name": "KIZU Junko"
}
],
"ja": [
{
"name": "木津 純子"
},
{
"name": "歌野智之"
},
{
"name": "田中庸一"
},
{
"name": "木津純子"
},
{
"name": "神谷尚宏"
},
{
"name": "小川千登世"
},
{
"name": "石田也寸志"
},
{
"name": "細谷亮太"
},
{
"name": "真部淳"
}
]
},
"description": {
"ja": "【背景】メルカプトプリン(6-MP)及びメトトレキサート(MTX)の臨床効果や副作用は個体差が大きく,個々によって至適投与量は大きく異なる事が知られている.本研究は,両薬剤の投与量推移を調査し,患者背景及び再発との関連性について調査した.【方法】1995年4月~2010年3月の期間に当施設で急性リンパ性白血病(ALL)と診断され,維持療法が終了した患児を対象とした.両薬剤の投与量推移を調査し,投与量推移別に患者背景(性別,診断時:白血球数,年齢,immunophenotype,維持療法開始時:体表面積,Prednisolone反応性,リスク分類,肥満度)を比較した.また,再発患者と非再発患者の6-MP及びMTXの投与量推移を比較した.【結果】維持療法開始1年以内に6-MP投与量の変更を要した患児は50名中34名(増量20名,減量14名),MTX投与量の変更を要した患児は50名中18名(増量3名,減量15名)であった.投与量因子の検討では,6-MP及びMTXの投与量の変更を要した事と患者背景に関連性は認められなかった.また,再発を来した患者7名中4名において維持療法開始6ヶ月以内に50%以上の6-MPの増量が必要であった.【結論】維持療法における6-MP及びMTXの投与量推移は,本研究においても個体差が大きい事が認められた.また,6-MP及びMTX投与量推移と患者背景との関連性は認められなかった.しかしながら,6-MPの維持療法早期の増量と再発は関連する可能性がある.",
"en": "Background. Mercaptopurine (6-MP) and methotrexate (MTX) form the backbone of maintenance therapy for childhood acute lymphoblastic leukemia (ALL). It is widely noted that the inter- and intrapatient variations in the clinical efficacy and adverse effects of 6-MP and MTX are enormous, and optimal dosage varies considerably. The aim of this study was to elucidate the factors that affect the optimal dosage setting of 6-MP/MTX in the maintenance phase of treatment. Methods. Fifty children (aged 1 to 15) who were diagnosed as having ALL in our institution between April 1995 to March 2010 and who finished maintenance therapy were enrolled in this study. We investigated the 6-MP/MTX dosages from the beginning (6-MP/MTX: 40 mg/m2 / 25 mg/m2) and compared patients' characteristics (sex, white blood cell count, age, immunophenotype, body surface area, prednisolone response, risk classification, obesity index) and relapse rates across each category. Results. Thirty-four patients needed to change their 6-MP dosage (increase, n=20; decrease, n=14), whereas 18 patients needed to change their MTX dosage (increase, n=3; decrease, n=15). The patients' characteristics were not significantly different in each category of dosage changes; on the other hand, it was shown that 4 of 7 relapse patients experienced an increase in 6-MP dosage of more than 50% within the first 6 months after the start of maintenance treatment. Conclusions. In this study, we conclude that the patients' characteristics are not related to the 6-MP/MTX dosage change in maintenance therapy, and it is suggested that the major increase in 6-MP dosage may predict the occurrence of relapse."
},
"publisher": {
"ja": "日本小児血液・がん学会",
"en": "The Japanese Society of Pediatric Hematology / Oncology"
},
"publication_date": "2015-09",
"publication_name": {
"ja": "日本小児血液・がん学会誌",
"en": "日本小児血液・がん学会誌"
},
"volume": "52",
"number": "5",
"starting_page": "399",
"ending_page": "404",
"languages": [
"jpn"
],
"referee": true,
"invited": false,
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"doi": [
"10.11412/jspho.52.399"
],
"issn": [
"2187-011X"
],
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"130005125286"
]
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"paper_title": {
"ja": "医学部・看護学部・薬学部における感染制御教育の実態.",
"en": "医学部・看護学部・薬学部における感染制御教育の実態."
},
"authors": {
"ja": [
{
"name": "木津 純子"
},
{
"name": "木津純子"
},
{
"name": "堀誠治"
},
{
"name": "岩田敏"
}
],
"en": [
{
"name": "KIZU Junko"
}
]
},
"publication_date": "2015-08",
"publication_name": {
"ja": "日本環境感染学会誌",
"en": "日本環境感染学会誌"
},
"volume": "30",
"starting_page": "202",
"ending_page": "206",
"languages": [
"jpn"
],
"referee": true,
"invited": false,
"published_paper_type": "scientific_journal",
"rm:is_open_access": false,
"identifiers": {
"doi": [
"10.4058/jsei.30.202"
]
},
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{
"label": "doi",
"@id": "https://doi.org/10.4058/jsei.30.202",
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{
"@id": "https://api.researchmap.jp/read0064779/published_papers/16702947",
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"rm:modified": "2020-09-01T01:59:35Z",
"paper_title": {
"en": "Pharmacokinetics and skin-tissue penetration of daptomycin in rats"
},
"authors": {
"en": [
{
"name": "Kazuaki Matsumoto"
},
{
"name": "Masashi Kitaoka"
},
{
"name": "Yuko Kuroda"
},
{
"name": "Kazuro Ikawa"
},
{
"name": "Norifumi Morikawa"
},
{
"name": "Junichi Sasaki"
},
{
"name": "Osamu Iketani"
},
{
"name": "Satoshi Iwata"
},
{
"name": "Tetsuya Horino"
},
{
"name": "Seiji Hori"
},
{
"name": "Junko Kizu"
}
]
},
"description": {
"en": "Background: Daptomycin is recommended for complicated skin and skin-structure infections. However, information on the penetration of daptomycin into skin is limited. Therefore, the aim of this in vivo investigation was to determine the pharmacokinetics and skin penetration of daptomycin in rats. Materials and methods: Concentrations of daptomycin were determined by high-performance liquid chromatography. A noncompartmental pharmacokinetic analysis was conducted to estimate the rate and extent of daptomycin penetration from the systemic circulation into skin tissue. Since protein binding of daptomycin in rat serum was 89.3%, the free maximum concentration (C<\ninf>\nmax<\n/inf>\n) and free area under the curve from time 0 to infinity (AUC<\ninf>\n0-∞<\n/inf>\n) for plasma were calculated as follows: fC<\ninf>\nmax,plasma<\n/inf>\n = (1 - 0.893) × C<\ninf>\nmax,plasma<\n/inf>\n, fAUC<\ninf>\n0-∞<\n/inf>\n,<\ninf>\nplasma<\n/inf>\n = (1 - 0.893) × AUC<\ninf>\n0-∞,plasma<\n/inf>\n. Results: The following values (mean ± standard deviation) were obtained: 0.06±0 L/h/kg for total clearance (CL<\ninf>\ntotal<\n/inf>\n), 0.44±0.06 hours for elimination-rate constant, 1.58±0.23 hours for half-life, 0.14±0.02 L/kg for steady-state volume distribution, and 2.28±0.33 hours for mean residence time. Time to C<\ninf>\nmax<\n/inf>\n was 3.0 hours for plasma and skin tissue. C<\ninf>\nmax<\n/inf>\n and AUC0-∞ for plasma were 175.8±5.1 μg/mL and 811.8±31.9 μg × h/mL, respectively. C<\ninf>\nmax<\n/inf>\n and AUC<\ninf>\n0-∞<\n/inf>\n for skin tissue were 19.1±1.7 μg/mL and 113.9±21.8 μg × h/mL, respectively. Furthermore, fCmax and fAUC<\ninf>\n0-∞<\n/inf>\n for plasma were 18.8 μg/mL and 86.9 μg × h/mL, respectively. The degrees of skin-tissue penetration, defined as the C<\ninf>\nmax<\n/inf>\n, skin tissue/fC<\ninf>\nmax<\n/inf>\n, plasma ratio and<\ninf>\nAUC0-∞, skin tissue<\n/inf>\n/fAUC<\ninf>\n0-∞, plasma<\n/inf>\n ratio, were 1.0 and 1.3, respectively. Conclusion: Daptomycin exhibited good penetration into skin tissue, supporting its use for the treatment of complicated skin and skin-structure infections. However, further studies are needed in infected patients in order to investigate the relationship between the antimicrobial efficacy of daptomycin and its drug concentrations in skin tissues."
},
"publisher": {
"en": "Dove Medical Press Ltd"
},
"publication_date": "2015-05-21",
"publication_name": {
"en": "Clinical Pharmacology: Advances and Applications"
},
"volume": "7",
"starting_page": "79",
"ending_page": "82",
"languages": [
"eng"
],
"referee": true,
"invited": false,
"published_paper_type": "scientific_journal",
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"identifiers": {
"doi": [
"10.2147/CPAA.S83447"
],
"issn": [
"1179-1438"
],
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"84930948033"
]
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"paper_title": {
"en": "Pharmacokinetics and dosing estimation of meropenem in Japanese patients receiving continuous venovenous hemodialysis"
},
"authors": {
"en": [
{
"name": "Shinji Kawano"
},
{
"name": "Kazuaki Matsumoto"
},
{
"name": "Ryohei Hara"
},
{
"name": "Yuko Kuroda"
},
{
"name": "Kazuro Ikawa"
},
{
"name": "Norifumi Morikawa"
},
{
"name": "Tetsuya Horino"
},
{
"name": "Seiji Hori"
},
{
"name": "Junko Kizu"
}
]
},
"description": {
"en": "The pharmacokinetics of meropenem have not yet been examined in Japanese patients receiving Continuous venovenous hemodialysis (CVVHD). The aim of this clinical investigation was to determine the pharmacokinetic parameters of meropenem in critically ill patients receiving CVVHD in order to estimate dosing regimens for the patient population in Japan. The values of pharmacokinetic parameters were 17.5 +/- 5.6 I for V-1, 1.27 +/- 0.38 h(-1) for K-12, 0.71 +/- 0.40 h(-1) for K-12 and 0.17 +/- 0.02 h(-1) for K-10. Based on these mean parameters (V-1, K-12, K-12 and K-10), time above MIC (T > MIC) values were estimated at different MICs using various meropenem regimens. For bacteria with a meropenem MIC of <= 2 mu g/ml, a dosing regimen of 0.25 g every 24 h achieved more than 40% T > MIC. For a MIC of 4 mu g/ml, all the regimens tested, except for 0.25 g every 24 h, achieved more than 40% T > MIC. For a MIC of 16 mu g/ml, dosing regimens of 0.5 g every 8 h, 1 g every 12 h, and I g every 8 h achieved 40% T> MIC, reaching the pharmacokinetic-pharmacodynamic target range. This is the first study to examine the pharmacokinetics of meropenem under a CVVHD setting in Japan. The pharmacokinetic-pharmacodynamic profile of dosing regimens tested in this study will assist in selecting the appropriate meropenem regimens for patients receiving CVVHD. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved."
},
"publisher": {
"en": "ELSEVIER SCIENCE BV"
},
"publication_date": "2015-05",
"publication_name": {
"en": "JOURNAL OF INFECTION AND CHEMOTHERAPY"
},
"volume": "21",
"number": "5-6",
"starting_page": "476",
"ending_page": "478",
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"eng"
],
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"doi": [
"10.1016/j.jiac.2015.02.011"
],
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"1341-321X"
],
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"1437-7780"
],
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"WOS:000356842300028"
]
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"@id": "https://doi.org/10.1016/j.jiac.2015.02.011",
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{
"@id": "https://api.researchmap.jp/read0064779/published_papers/16702949",
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"paper_title": {
"ja": "医薬品副作用被害救済制度からみた一般用医薬品が関連した副作用被害の実態",
"en": "医薬品副作用被害救済制度からみた一般用医薬品が関連した副作用被害の実態"
},
"authors": {
"ja": [
{
"name": "木津 純子"
},
{
"name": "医薬品副作用被害救済制度からみた一般用医薬品が関連した副作用被害の実態"
},
{
"name": "黒田裕子"
},
{
"name": "松元一明"
},
{
"name": "木津純子"
}
],
"en": [
{
"name": "KIZU Junko"
}
]
},
"publication_date": "2015-04",
"publication_name": {
"ja": "日本病院薬剤師会雑誌",
"en": "日本病院薬剤師会雑誌"
},
"volume": "51",
"starting_page": "425",
"ending_page": "428",
"languages": [
"jpn"
],
"referee": true,
"invited": false,
"published_paper_type": "scientific_journal",
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},
{
"@id": "https://api.researchmap.jp/read0064779/published_papers/16702948",
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"rm:modifier_type": "ai",
"rm:modified": "2022-09-24T10:08:48Z",
"paper_title": {
"ja": "薬学臨床系教員の現状に関するアンケート調査(第2報)",
"en": "薬学臨床系教員の現状に関するアンケート調査(第2報)"
},
"authors": {
"en": [
{
"name": "KIZU Junko"
}
],
"ja": [
{
"name": "木津 純子"
},
{
"name": "野田 幸裕"
},
{
"name": "矢野 育子"
},
{
"name": "青山 隆夫"
},
{
"name": "渡邊 美智留"
},
{
"name": "今田 愛也"
},
{
"name": "中村 均"
},
{
"name": "松下 良"
},
{
"name": "森田 邦彦"
},
{
"name": "三宅 勝志"
},
{
"name": "瀬尾 量"
},
{
"name": "上村 直樹"
},
{
"name": "富岡 佳久"
},
{
"name": "木津 純子"
},
{
"name": "望月 眞弓"
}
]
},
"description": {
"ja": "In 2012 we conducted a questionnaire survey to clarify the current state of pharmacy-related universities and clinical faculties and identify problem areas in pharmacy education and research. The survey was sent to 74 universities nationwide; responses were received from 488 out of 530 faculties distributed at 59 universities. The male/female ratio of the respondents was 3:1 and the age breakdown was 24% aged 30-years or younger, 61% aged 40-50-years. Regarding interest in education and research, 62% of the respondents emphasized education over research; the weekly average time devoted to these respective activities was 21 hours for education and 13 hours for research. Of the respondents, 46% had not even practiced once in 2012, while 61% out of the responders who had practiced (52%) had engaged in practice in a clinical setting one day per week or more. As for research, 83% and 20% of respondents supervised undergraduate and PhD students, respectively. Despite the fact that roughly half of all respondents do not fully engage in practice and research, satisfaction with the current situation on a 5-point scale was 35% for \"satisfied\" and \"somewhat satisfied\" combined, and 40% for \"acceptable.\" Clinical faculties should not be content with the present situation and should strive to advance education and research by enhancing motivation to train the next generation. It is hoped that future discussions will lead to the revitalization of practice/education/research among clinical faculties, and also to the training of staff in clinical faculties, in whose footsteps the pharmacy students and/or next generation pharmacists can aspire to follow.",
"en": "In 2012 we conducted a questionnaire survey to clarify the current state of pharmacy-related universities and clinical faculties and identify problem areas in pharmacy education and research. The survey was sent to 74 universities nationwide; responses were received from 488 out of 530 faculties distributed at 59 universities. The male/female ratio of the respondents was 3:1 and the age breakdown was 24% aged 30-years or younger, 61% aged 40-50-years. Regarding interest in education and research, 62% of the respondents emphasized education over research; the weekly average time devoted to these respective activities was 21 hours for education and 13 hours for research. Of the respondents, 46% had not even practiced once in 2012, while 61% out of the responders who had practiced (52%) had engaged in practice in a clinical setting one day per week or more. As for research, 83% and 20% of respondents supervised undergraduate and PhD students, respectively. Despite the fact that roughly half of all respondents do not fully engage in practice and research, satisfaction with the current situation on a 5-point scale was 35% for \"satisfied\" and \"somewhat satisfied\" combined, and 40% for \"acceptable.\" Clinical faculties should not be content with the present situation and should strive to advance education and research by enhancing motivation to train the next generation. It is hoped that future discussions will lead to the revitalization of practice/education/research among clinical faculties, and also to the training of staff in clinical faculties, in whose footsteps the pharmacy students and/or next generation pharmacists can aspire to follow."
},
"publisher": {
"ja": "一般社団法人日本医療薬学会",
"en": "Japanese Society of Pharmaceutical Health Care and Sciences"
},
"publication_date": "2015-04",
"publication_name": {
"ja": "医療薬学",
"en": "医療薬学"
},
"volume": "41",
"number": "4",
"starting_page": "223",
"ending_page": "235",
"languages": [
"jpn"
],
"referee": true,
"invited": false,
"published_paper_type": "scientific_journal",
"rm:is_open_access": false,
"identifiers": {
"doi": [
"10.5649/jjphcs.41.223"
],
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"1346-342X"
],
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"130005144095"
]
},
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"@id": "https://doi.org/10.5649/jjphcs.41.223",
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"ja": "バンコマイシン塩酸塩点滴静注用製剤の生理食塩液に対する溶解性比較.",
"en": "バンコマイシン塩酸塩点滴静注用製剤の生理食塩液に対する溶解性比較."
},
"authors": {
"ja": [
{
"name": "松元一明"
},
{
"name": "黒田裕子"
},
{
"name": "寺島朝子"
},
{
"name": "前澤佳代子"
},
{
"name": "木津純子"
}
],
"en": [
{
"name": "松元一明"
},
{
"name": "黒田裕子"
},
{
"name": "寺島朝子"
},
{
"name": "前澤佳代子"
},
{
"name": "木津純子"
}
]
},
"publication_date": "2015-01",
"publication_name": {
"ja": "日本環境感染学会誌",
"en": "日本環境感染学会誌"
},
"volume": "30",
"number": "1",
"starting_page": "29",
"ending_page": "32",
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"jpn"
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"paper_title": {
"ja": "診療報酬改定による医療施設の感染防止対策の変化",
"en": "診療報酬改定による医療施設の感染防止対策の変化"
},
"authors": {
"en": [
{
"name": "KIZU Junko"
}
],
"ja": [
{
"name": "前澤 佳代子"
},
{
"name": "寺島 朝子"
},
{
"name": "黒田 裕子"
},
{
"name": "堀 誠治"
},
{
"name": "木津 純子"
}
]
},
"description": {
"ja": "医療現場での感染防止対策について,感染防止対策加算に関わる診療報酬改定を経てどのように変化したか,アンケートによる実態調査を実施した.2008年5月に第1回調査,2010年4月加算新設後の2011年1月に第2回調査,2012年4月加算改定後の2013年8月に第3回調査を行った.全国有床診療施設より抽出した1000施設に調査を依頼した.ICT設置率は,第1回(回答539施設)78%,第2回(494施設)77%であったが,第3回(574施設)では88%に増加していた.加算の算定率は,第2回調査においては46%であり,その9割が300床以上であった.第3回調査では85%(加算1:60%,加算2:25%)となり,300床未満の施設の算定率が上昇した.算定による変化として,ICTラウンドの頻度の増加が挙げられ,\"週一回以上\"実施している施設が16%, 35%, 54%と増加した.さらに,抗菌薬管理を強化した施設も多く,カルバペネム系薬の許可制・届出制を導入している施設は45%, 59%, 75%に増加した.注射用抗MRSA薬もいずれも同様に増加し,第3回調査では全て70%以上であった.その他,ICT及び専門職種の増員などが行われた.以上より,2012年4月の加算改定により,施設の病床規模によらず,感染対策に対する取り組みや体制作りが一層推進され,各施設の感染防止対策が充実してきていることが確認された.
",
"en": "To clarify changes in infection control in medical facilities after the revision of medical fees, including those for infection control, questionnaire surveys were conducted in May 2008, January 2011, and August 2013; the second and third surveys were made after the revisions of medical fees in April 2010 and April 2012, respectively. A total of 1,000 facilities were selected from medical facilities with beds throughout Japan, and were asked to cooperate with the study; 539, 494, and 574 facilities participated in the first, second, and third surveys, respectively. The infection control team (ICT) availability rate in each survey was 78% (539 responses), 77% (494), and 88% (574), respectively; a marked increase in the rate was observed in the third survey. The rate of facilities charging additional fees was 46% in the second survey, 90% of which had 300 beds or more, and 85% in the third survey (additional fee category 1: 60%; 2: 25%), with a marked increase in the proportion of facilities with less than 300 beds. These changes in additional fee charges may be explained by the increased frequency of ICT rounds. During the study period, the rates of facilities making 1 or more ICT rounds weekly increased from 16% in the first survey to 35% in the second and 54% in the third surveys. Furthermore, antibacterial drug management was promoted in a large number of facilities, and rates of facilities requiring permission or reporting for carbapenem use increased from 45% in the first survey to 59% in the second and 75% in the third surveys. A similar tendency was also observed in relation to anti–MRSA injections, with the rate was higher than 70% in the third survey. The numbers of ICT members and other specialists had also increased. These findings confirm that infection control approaches and systems have been strengthened in medical facilities, regardless of the number of beds, since the revision of medical fees in April 2012.
"
},
"publisher": {
"ja": "Japanese Society for Infection Prevention and Control",
"en": "Japanese Society for Infection Prevention and Control"
},
"publication_date": "2014-11",
"publication_name": {
"ja": "日本環境感染学会誌",
"en": "日本環境感染学会誌"
},
"volume": "29",
"number": "6",
"starting_page": "429",
"ending_page": "436",
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"paper_title": {
"ja": "複合型塩素系除菌・洗浄用製剤の安定性と色調の変化",
"en": "複合型塩素系除菌・洗浄用製剤の安定性と色調の変化"
},
"authors": {
"en": [
{
"name": "KIZU Junko"
}
],
"ja": [
{
"name": "木津 純子"
},
{
"name": "高木 奏"
},
{
"name": "黒田 裕子"
},
{
"name": "前澤 佳代子"
},
{
"name": "松元 一明"
},
{
"name": "堀 誠治"
}
]
},
"description": {
"ja": "複合型塩素系除菌・洗浄用製剤は1錠を500 mLの水道水で溶解して調製する製剤(有効塩素濃度0.1%;本製剤)で,調製液は淡赤色を呈する.調製液の安定性と色調の変化について検討した.
調製液をガラス製気密容器に入れ,1)室内散乱光下(23–30°C),2)直射日光下(24–34°C),3)室温遮光下,4)高温(40°C)遮光下,5)冷所(4°C)遮光下で保存し,調製直後,3, 7, 14日後の有効塩素濃度(ヨウ素滴定法で測定),pH, 520 nmにおける吸光度を測定した.対照として0.1%次亜塩素酸ナトリウム溶液の有効塩素濃度,pHを測定した.
有効塩素濃度は,7・14日後には1)71%・58%, 2)68%・53%, 3)70%・59%, 4)44%・17%, 5)93%・89%に低下し,温度が安定性に影響することが確認された.pHおよび吸光度も,有効塩素濃度と同様の低下を示した.また,調製液の色調は有効塩素濃度を反映することが確認された.0.1%次亜塩素酸ナトリウム溶液の有効塩素濃度は,1)95%・91%, 2)54%・32%に低下したが,3)・4)・5)は変化せず,直射日光が安定性に影響していた.pHはほぼ一定であった.
以上より,本製剤は室温保存で徐々に有効塩素濃度が低下し,1週間が有効期間である.ただし高温を避けて保存する必要がある.また,有効塩素濃度の低下が色調に良好に反映され,色調の観察により残存濃度を確認できることが示された.
",
"en": "The complex-type chlorine-based disinfectant cleaner is a tablet-type agent which is dissolved in 500 mL of tap water, and the prepared solution (0.1% of available chlorine) displays a light red color. The stability and color degradation of the prepared solution were examined. The prepared solution was put into airtight glass containers and stored under the following conditions: 1) under room light at 23℃ to 30℃, 2) under direct sunlight at 24℃ to 34℃, 3) under shaded conditions at room temperature, 4) under shaded conditions at high temperature (40℃), and 5) under shaded conditions at 4℃. The available chlorine concentration (measured by an iodine titration technique), pH, and absorbance at 520 nm of the prepared solution were measured immediately, and 3, 7, and 14 days after preparation. The available chlorine concentration and pH of 0.1% sodium hypochlorite solution were measured as controls. The available chlorine concentration of the prepared solution fell under the various test conditions to 1) 71% and 58%, 2) 68% and 53%, 3) 70% and 59%, 4) 44% and 17%, and 5) 93% and 89%, at 7 days and 14 days after preparation, respectively. The temperature of the storage area clearly affected the stability of the prepared solution. pH, absorbance, and available chlorine concentration of the prepared solution were all reduced. Moreover, the color degradation of the prepared solution reflected the available chlorine concentration. The available chlorine concentration of 0.1% sodium hypochlorite solution fell under conditions 1) 95% and 91% and 2) 54% and 32%, at 7 days and 14 days after preparation, respectively, but not under conditions 3), 4), and 5). The available chlorine concentration of 0.1% sodium hypochlorite solution fell under direct sunlight, but pH was almost constant under all conditions. These findings show that the available chlorine concentration of a prepared solution falls gradually at room temperature, and the prepared solution retains the required properties for one week. However, high temperature storage must be avoided. In addition, the decrease of available chlorine concentration is well reflected in the color intensity, so that the residual available chlorine concentration can be checked by observation of the solution color.
"
},
"publisher": {
"ja": "Japanese Society for Infection Prevention and Control",
"en": "Japanese Society for Infection Prevention and Control"
},
"publication_date": "2014-11",
"publication_name": {
"ja": "日本環境感染学会誌",
"en": "日本環境感染学会誌"
},
"volume": "29",
"number": "6",
"starting_page": "411",
"ending_page": "416",
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"jpn"
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"paper_title": {
"ja": "カラゲニン足蹠浮腫モデルを用いた各種ケトプロフェンテープ剤の抗炎症効果比較",
"en": "カラゲニン足蹠浮腫モデルを用いた各種ケトプロフェンテープ剤の抗炎症効果比較"
},
"authors": {
"en": [
{
"name": "KIZU Junko"
}
],
"ja": [
{
"name": "松元 一明"
},
{
"name": "河野 倫也"
},
{
"name": "杉山 哲也"
},
{
"name": "坂本 靖宜"
},
{
"name": "島田 亜由美"
},
{
"name": "黒田 裕子"
},
{
"name": "寺島 朝子"
},
{
"name": "前澤 佳代子"
},
{
"name": "木津 純子"
}
]
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"description": {
"ja": "カラゲニン足蹠浮腫モデルを用いた各種ケトプロフェンテープ剤の抗炎症効果について検討した。先発医薬品のモーラステープ20mg(A)、後発医薬品のケトプロフェンテープ20mg「テイコク」(B)、ケトプロフェンテープ20mg「東光」(C)、ケトプロフェンテープ20mg「日医工」(D)、タッチロンテープ20(E)、パテルテープ20(F)、フレストルテープ20(G)、レイナノンテープ20mg(H)、ロマールテープ20(I)を用いた。カラゲニンによる足蹠浮腫は3時間後にピークに達した。製剤間における浮腫抑制効果を比較検討し、製剤Aおよび製剤BのAUC0-5hは有意に低値を示したが、製剤CからIは低下傾向は示したが有意差は認めかった。製剤Aの消失量は、製剤E、F、G、Iに比べ有意に低値を示した。ケトプロフェンテープ剤貼付3時間後におけるケトプロフェン消失量が多いほど浮腫率は小さくなり、相関関係を認めた。"
},
"publisher": {
"ja": "日本医療薬学会",
"en": "日本医療薬学会"
},
"publication_date": "2014-11",
"publication_name": {
"ja": "医療薬学",
"en": "医療薬学"
},
"volume": "40",
"number": "11",
"starting_page": "672",
"ending_page": "676",
"languages": [
"jpn"
],
"referee": true,
"invited": false,
"published_paper_type": "scientific_journal",
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"identifiers": {
"issn": [
"1346-342X"
],
"e_issn": [
"1882-1499"
],
"jamas_id": [
"2015248519"
],
"doi": [
"10.5649/jjphcs.40.672"
]
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"paper_title": {
"ja": "Maternal plasma and breast milk concentration of labetalol administrated to lactating women and infantile findings.",
"en": "Maternal plasma and breast milk concentration of labetalol administrated to lactating women and infantile findings."
},
"authors": {
"ja": [
{
"name": "Uematsu k"
},
{
"name": "Kobayashi E"
},
{
"name": "Katsumoto E"
},
{
"name": "Matsumoto H"
},
{
"name": "Kawai S"
},
{
"name": "Sugimoto M"
},
{
"name": "Kawakami T"
},
{
"name": "Terajima T"
},
{
"name": "Maezawa K"
},
{
"name": "Kizu J"
}
],
"en": [
{
"name": "Uematsu k"
},
{
"name": "Kobayashi E"
},
{
"name": "Katsumoto E"
},
{
"name": "Matsumoto H"
},
{
"name": "Kawai S"
},
{
"name": "Sugimoto M"
},
{
"name": "Kawakami T"
},
{
"name": "Terajima T"
},
{
"name": "Maezawa K"
},
{
"name": "Kizu J"
}
]
},
"publication_date": "2014-06",
"publication_name": {
"ja": "J Japanese Society for Breastfeeding Research",
"en": "J Japanese Society for Breastfeeding Research"
},
"volume": "8(1)",
"starting_page": "72-80",
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"eng"
],
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"paper_title": {
"en": "The efficacy, safety, and pharmacokinetics of biapenem administered thrice daily for the treatment of pneumonia in the elderly"
},
"authors": {
"en": [
{
"name": "Ho Namkoong"
},
{
"name": "Youjyu Kameyama"
},
{
"name": "Hiroyuki Yasuda"
},
{
"name": "Sohei Nakayama"
},
{
"name": "Hiroshi Kaneko"
},
{
"name": "Chieko Kawashima"
},
{
"name": "Tomoko Terajima"
},
{
"name": "Kayoko Maezawa"
},
{
"name": "Takeshi Hayashi"
},
{
"name": "Mitsuru Sandoh"
},
{
"name": "Makoto Ishii"
},
{
"name": "Sadatomo Tasaka"
},
{
"name": "Akiko Kanayama"
},
{
"name": "Intetsu Kobayashi"
},
{
"name": "Tomoko Betsuyaku"
},
{
"name": "Junko Kizu"
},
{
"name": "Satoshi Iwata"
},
{
"name": "Yoshitake Sato"
},
{
"name": "Naoki Hasegawa"
}
]
},
"description": {
"en": "Biapenem has been widely used to treat bacterial pneumonia; however, there is little information concerning its efficacy and safety in elderly patients. Based on pharmacokinetic-pharmacodynamic theory, administration of biapenem thrice rather than twice daily would be expected to be more effective because of longer time above the minimum inhibitory concentration. In this study, we aimed to evaluate the efficacy, safety, and pharmacokinetics of biapenem (300 mg) administered thrice daily in pneumonic patients aged 65 years or older. Biapenem was effective in 22 of 25 patients, as assessed by the improvement in clinical symptoms and/or the eradication of the causative organisms, and caused no serious adverse events. The pharmacokinetic profile was established based on simulations using a modeling program. Among 17 patients whose causative organisms were detected, time above the minimum inhibitory concentration was estimated to be 100% in 16 patients, all of whom showed clinical improvement. The results of this study confirmed the efficacy and safety of 300 mg of biapenem administered thrice daily for the treatment of pneumonia in elderly patients. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved."
},
"publisher": {
"en": "SPRINGER JAPAN KK"
},
"publication_date": "2014-05",
"publication_name": {
"en": "JOURNAL OF INFECTION AND CHEMOTHERAPY"
},
"volume": "20",
"number": "5-6",
"starting_page": "356",
"ending_page": "360",
"languages": [
"eng"
],
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"invited": false,
"published_paper_type": "scientific_journal",
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"identifiers": {
"doi": [
"10.1016/j.jiac.2013.12.010"
],
"issn": [
"1341-321X"
],
"e_issn": [
"1437-7780"
],
"wos_id": [
"WOS:000338270600015"
]
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"@id": "https://doi.org/10.1016/j.jiac.2013.12.010",
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"@id": "https://api.researchmap.jp/read0064779/published_papers/16702956",
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"paper_title": {
"ja": "医療従事者における流行性ウイルス感染症の抗体価測定とワクチン接種.",
"en": "医療従事者における流行性ウイルス感染症の抗体価測定とワクチン接種."
},
"authors": {
"en": [
{
"name": "武重彩子"
},
{
"name": "山口正和"
},
{
"name": "岩田 敏"
},
{
"name": "前澤佳代子"
},
{
"name": "木津純子"
}
],
"ja": [
{
"name": "武重彩子"
},
{
"name": "山口正和"
},
{
"name": "岩田 敏"
},
{
"name": "前澤佳代子"
},
{
"name": "木津純子"
}
]
},
"description": {
"ja": "同意が得られた医療従事者838名を対象とし,麻疹,風疹,ムンプス,水痘の罹患歴,予防接種歴について自己申告するとともに,各ウイルス抗体価を測定し,抗体保有状況を調査した.麻疹はPA法(ワクチン接種対象者は128倍以下とした)およびEIA法(4.0未満),風疹はHI法(8倍以下)およびEIA法(4.0未満),ムンプスおよび水痘はEIA法(4.0未満)で測定し,抗体価の低い希望者にワクチンを接種した.いずれかの抗体価が低い医療従事者が28.0%おり,ワクチン接種の対象となった割合は,麻疹7.4%,風疹8.4%,ムンプス16.1%,水痘0.8%であった.罹患率,予防接種歴の自己申告と抗体価との関連性は低かった.抗体獲得率は,麻疹PA法86.3%,EIA法100.0%,風疹HI法93.3%,EIA法98.3%,ムンプス82.9%,水痘100.0%であった.ワクチン接種による有害事象は麻疹・風疹混合ワクチン44.7%,ムンプスワクチン37.1%,水痘ワクチン66.7%に発現したが,いずれも軽快し,直接ワクチン接種との因果関係が疑われる重篤な症状は認められなかった.本研究により,罹患歴,予防接種歴があると自己申告している者にも,ワクチン接種の対象者がおり,全職員の抗体価測定が有用であることが認められた.さらに,低抗体価の職員へのワクチン接種が有効であり,かつ安全であることが確認された.
",
"en": "This study included 838 medical professionals who had provided consent. We asked them to report on previous histories of infection by measles, rubella, mumps, and varicella viruses as well as vaccination, and surveyed whether they carried an antibody to each of these viruses by determining the antibody titers. The determination was based on a PA method (a subject was considered as a candidate for vaccination if his/her titer was 1 : 128 or below) and EIA (less than 4.0) for measles, HI (1 : 8 or below) and EIA (less than 4.0) for rubella, and EIA (less than 4.0) for mumps and varicella. The subjects with a lower titer received vaccination if they so desired. The antibody titer to any of the viruses was low in 28% of the subjects; the percentage of the subjects being a candidate for vaccination was 7.4% for measles, 8.4% for rubella, 16.1% for mumps, and 0.8% for varicella. The self-reported prevalence rates and vaccination histories were poorly associated with the antibody titers. The antibody acquisition rates were 86.3 and 100.0% for PA and EIA, respectively, in measles, 93.3 and 98.3 for HI and EIA, respectively, in rubella, 82.9 in mumps, and 100.0 in varicella. Adverse events occurred due to vaccination at an incidence of 44.7% for measles/rubella virus, 37.1 for mumps, and 66.7 for varicella; all events were resolved, without serious symptoms possibly directly related to the vaccination. These results demonstrated that vaccination is also applicable to some individuals who report a history of a target disease or previous vaccination, suggesting the appropriateness of measuring antibody titers in all staff members. Furthermore, in this study, the effectiveness and safety of vaccination for those with a low titer were confirmed.
"
},
"publisher": {
"ja": "Japanese Society for Infection Prevention and Control",
"en": "Japanese Society for Infection Prevention and Control"
},
"publication_date": "2014-01",
"publication_name": {
"ja": "日本環境感染学会誌",
"en": "日本環境感染学会誌"
},
"volume": "29(1)",
"number": "1",
"starting_page": "23-31",
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"jpn"
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"doi": [
"10.4058/jsei.29.23"
],
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"1882-532X"
],
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"130003394998"
],
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"AA12313188"
]
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"paper_title": {
"ja": "A retrospective review of the risk factors for infection in cancer patients receiving specialist palliative care.",
"en": "A retrospective review of the risk factors for infection in cancer patients receiving specialist palliative care."
},
"authors": {
"ja": [
{
"name": "Yajima R"
},
{
"name": "Ise Y"
},
{
"name": "Wako T"
},
{
"name": "Katayama S"
},
{
"name": "Kizu J"
}
],
"en": [
{
"name": "Yajima R"
},
{
"name": "Ise Y"
},
{
"name": "Wako T"
},
{
"name": "Katayama S"
},
{
"name": "Kizu J"
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"ja": "J Nippon Med Sch",
"en": "J Nippon Med Sch"
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"eng"
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"doi": [
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"ja": "薬局における感染対策",
"en": "薬局における感染対策"
},
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"ja": [
{
"name": "木津 純子"
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{
"name": "KIZU Junko"
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"ja": "日本薬剤師会",
"en": "日本薬剤師会"
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"publication_name": {
"ja": "日本薬剤師会雑誌",
"en": "日本薬剤師会雑誌"
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"starting_page": "225",
"ending_page": "228",
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"paper_title": {
"ja": "小児薬物療法と薬用量における考え方",
"en": "小児薬物療法と薬用量における考え方"
},
"authors": {
"ja": [
{
"name": "木津 純子"
}
],
"en": [
{
"name": "KIZU Junko"
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},
"publication_date": "2015-04",
"publication_name": {
"ja": "小児科臨床",
"en": "小児科臨床"
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"volume": "68",
"number": "4",
"starting_page": "521",
"ending_page": "529",
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"misc_type": "introduction_commerce_magazine",
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"paper_title": {
"ja": "間違えのない滅菌消毒薬の取り扱い",
"en": "間違えのない滅菌消毒薬の取り扱い"
},
"authors": {
"ja": [
{
"name": "木津 純子"
},
{
"name": "松元一明"
},
{
"name": "木津純子"
}
],
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{
"name": "KIZU Junko"
}
]
},
"publication_date": "2015-01",
"publication_name": {
"ja": "感染対策ICTジャーナル",
"en": "感染対策ICTジャーナル"
},
"volume": "10",
"number": "1",
"starting_page": "13",
"ending_page": "18",
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"jpn"
],
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"paper_title": {
"ja": "添付文書はなぜ使いにくいのか?",
"en": "添付文書はなぜ使いにくいのか?"
},
"authors": {
"ja": [
{
"name": "木津 純子"
},
{
"name": "砂川 慶介"
},
{
"name": "戸塚 恭一"
},
{
"name": "堀 誠治"
},
{
"name": "木津 純子"
},
{
"name": "豊永 義清"
}
],
"en": [
{
"name": "KIZU Junko"
}
]
},
"publication_date": "2014-11",
"publication_name": {
"ja": "医薬品医療機器レギュラトリーサイエンス",
"en": "医薬品医療機器レギュラトリーサイエンス"
},
"volume": "45",
"number": "11",
"starting_page": "946",
"ending_page": "959",
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"jpn"
],
"referee": false,
"invited": false,
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"paper_title": {
"ja": "小児薬用量の考え方と小児薬物療法における注意点.",
"en": "小児薬用量の考え方と小児薬物療法における注意点."
},
"authors": {
"ja": [
{
"name": "鈴木小夜"
},
{
"name": "木津純子"
}
],
"en": [
{
"name": "鈴木小夜"
},
{
"name": "木津純子"
}
]
},
"publisher": {
"ja": "エルゼビア・ジャパン株式会社",
"en": "エルゼビア・ジャパン株式会社"
},
"publication_date": "2014-08",
"publication_name": {
"ja": "今日の臨床サポート",
"en": "今日の臨床サポート"
},
"starting_page": "www.clinicalsup.jp",
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"jpn"
],
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"paper_title": {
"ja": "文献レビュー:軟性消化器内視鏡の手動洗浄の評価に用いられてきた臨床基準値とチャネル検体採取方法の比較.",
"en": "文献レビュー:軟性消化器内視鏡の手動洗浄の評価に用いられてきた臨床基準値とチャネル検体採取方法の比較."
},
"authors": {
"ja": [
{
"name": "橋倉万由子"
},
{
"name": "木津純子"
}
],
"en": [
{
"name": "橋倉万由子"
},
{
"name": "木津純子"
}
]
},
"publisher": {
"ja": "協和企画",
"en": "協和企画"
},
"publication_date": "2014-07",
"publication_name": {
"ja": "CARLISLE",
"en": "CARLISLE"
},
"volume": "19(2)",
"starting_page": "9",
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"jpn"
],
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